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KMID : 0357919820160020217
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Korean Journal of Pathology
1982 Volume.16 No. 2 p.217 ~ p.230
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Serum Levels of Immunoglobulins(IgG, IgA & IgM) and Complement C3 in Healthy Korean
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서순팔(徐淳八)/Sang Pal Suh
박창수(朴彰洙)/유주용(柳柱容)/Chang Soo Park/Joo Yong
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Abstract
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This study attempted to estimate the mean concentration of immunoglobulins an4
complement in healthy Korean.
Serum concentrations of immunoglobulins and complements in healthy persons vary
with age, race and sax. 59, meaningful interpretation of strum levels of immunoglobulins
and complements in infants and aged Persons might have been difficult because of wide
range of normal value.
Recently, the great advance in methodology for the quantitation of immunogloculins
and complements has been achieved.
In the present report, the concentrations of the immunoglobulin(IgG, IgA and IgM)
and complement C3 were measured by Hyland Laser nephelometry in sera of 557
healthy Koreans. from birth to 70 Fears of age.
The results were as follows. .
1) The concentration of IgG in adult sera was 1551.8±391.1㎎/100㎖(mean±S.D.) in
male, 1723.0±385.6㎎/100㎖ in female: the level of IgM was 126.5±52.6㎎/100㎖ in male,
156.9±56.9㎎/100㎖ in female. The IgA value in adult sera was 250.6±105.7㎎/100㎖ in
mole, 269.1±97.9㎎/100㎖ in female; the mean level of C3 in adult sera wart 103.4±27.1
㎎/100㎖ in male and .105.5±28.0㎎/100㎖ in female.
The levels of IgG and IgM were higher in adult females than in adult males(P<0.005).
However, no significant differences were found on the levels of IgA and C3 between
adult males and females (p>0.05).
2) The average level of IgG in cord sera was similar to that of adult sera and lowest
at the 1 to 12 months of age, i.e., about 45 Per cent of adult level. In the groups of 6
to 12-years of age, the mean value of serum IgG approached the adult level in both
serves (P<0.005) .
3) In cord sera, IgA could, be defected in 53 per cent of all neonates. In the group of
1 to 12 months of age, serum IgA level revealed about 25 Per cent of adult value and it
was reached the adult level in the group of 13 to 18 Fears of age. No significant
difference was observed on the IgA level throughout all age groups in both sexes
(p>0.05) .
4) IgM was detected in all cord sera with been lees than 10 per cent of average adult
level. The serum IgM level in adult female was significantly higher than that of adult
male(P<0.005).
5) Concentration of C3 in cord sera was about 47 per cent of adult value and reached
the adult level within one year. No significant difference was noted on the C3 level
throughout all age groups in both sexes(p>0.05).
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